J Health Popul Nutr. 2025 Apr 13;44(1):116. doi: 10.1186/s41043-025-00852-z.
ABSTRACT
OBJECTIVE: To explore the clinical efficacy of commonly used conservative treatments for adenomyosis using both TCM and Western medicine.
METHODS: 210 patients with adenomyosis were selected and divided into 3 groups: Group A (Dan’e Fukang), Group B (Dienogest), and Group C (Goserelin + Mirena), with 70 cases in each group. Afterward, indicators were collected for comparison.
RESULTS: Different treatment approaches exhibited varying effects on uterine VAS, and PBAC among the 3 groups (P < 0.001). The effects of different treatment approaches on serum levels of estradiol (E2), FSH, and CA125 also differed among the 3 groups (P < 0.001). After 3 months of treatment, the incidence of adverse reactions among the 3 groups was significantly different (P < 0.001), with further comparison indicating a lower incidence of adverse reactions in Groups A and B than in Group C (P < 0.017). Meanwhile, statistically significant differences in the incidence of adverse reactions among the 3 groups were observed again after 6 months of treatment (P = 0.004), with further comparison revealing a lower incidence of adverse reactions in Group B than in Group C. Additionally, the comparison of uterine volume (P < 0.001) and VAS (P < 0.001) among the 3 groups was different after 12 months of treatment, and further comparison revealed that the uterine volume was ranked as Group B > Group C > Group A, while the pelvic pain VAS scores were ranked as Group C > Group B = Group A.
CONCLUSION: Dan’e Fukang Decoction is markedly effective in alleviating pain; Goserelin + Mirena exhibits significant efficacy in reducing bleeding.
PMID:40223114 | DOI:10.1186/s41043-025-00852-z
