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Remaining Challenges in the Treatment of Relapsed Wilms Tumor: Children’s Oncology Group and International Society of Paediatric Oncology Perspectives

Pediatr Blood Cancer. 2025 May 14:e31790. doi: 10.1002/pbc.31790. Online ahead of print.

ABSTRACT

Wilms tumor (WT) is the most common pediatric renal tumor, and with multidisciplinary treatment overall outcomes are excellent. However, a small subset of patients with WT will relapse. The ideal treatment of relapsed WT is yet to be defined. Ongoing studies through the Children’s Oncology Group Renal Tumors Committee (COG-RTC) and the International Society of Paediatric Oncology Renal Tumor Study Group (SIOP-RTSG) aim to improve risk stratification and treatment strategies. Members met at the SIOP 55th Annual Congress 2023 to outline available data and knowledge gaps and develop future research priorities.

PMID:40369656 | DOI:10.1002/pbc.31790

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