J Robot Surg. 2025 Jun 12;19(1):284. doi: 10.1007/s11701-025-02457-4.
ABSTRACT
This study aims to comprehensively assess the clinical performance of the Versius robotic platform in the context of robot-assisted radical prostatectomy (RARP), focusing on its safety profile, practicality, and postoperative functional recovery, in order to support its integration into urologic cancer management. An extensive literature search was performed using databases including PubMed, Embase, Web of Science, the Cochrane Library, and ClinicalTrials.gov, covering publications up to December 2024. The eligible studies were those reporting on perioperative metrics or functional outcomes associated with Versius-assisted RARP. Data extraction and synthesis were carried out under a single-arm meta-analytic framework. The aggregated measures such as operative duration, intraoperative blood loss, length of hospitalization, complication frequency, positive surgical margin (PSM) rate, and continence outcomes were calculated using Stata 18 SE. The study heterogeneity was quantified via the I2 statistic and sensitivity tests were performed to explore heterogeneity sources. A total of four studies comprising 145 patients were included. The pooled average duration of surgery was 190.63 min, with a mean blood loss of 320.35 mL. The rate of high-grade complications (Clavien-Dindo > II) was 7%, while the PSM rate stood at 32%. Continence recovery rates at 1, 2 and 3 months post-surgery were 43%, 65%, and 73%, respectively. Considerable inter-study heterogeneity was identified, possibly influenced by differences in surgical proficiency and Versius system configurations. The sensitivity analysis highlighted operative console time as a stable parameter, with reduced heterogeneity after removal of an outlier study. The study demonstrates that the Versius robotic platform achieves comparable oncological and functional results to conventional prostatectomy techniques, with the added advantage of potential cost savings, positioning it as a viable surgical option. Its modular structure and ergonomic enhancements present distinct benefits, although procedural variability persists. Additional high-quality, multi-institutional prospective studies are necessary to substantiate these preliminary findings and inform standardized surgical practices.
PMID:40504465 | DOI:10.1007/s11701-025-02457-4
