Retin Cases Brief Rep. 2025 Jun 20. doi: 10.1097/ICB.0000000000001779. Online ahead of print.
ABSTRACT
PURPOSE: To report three cases of acute choroidal ischemia in patients diagnosed with catastrophic antiphospholipid syndrome (CAPS).
METHODS: The medical and imaging records of patients with CAPS were retrospectively reviewed. Patients underwent retinal imaging, including fundus photography, spectral-domain optical coherence tomography (SD-OCT), fluorescein and indocyanine green angiography.
RESULTS: This report summarizes three cases of pregnant women (six eyes) with CAPS and posterior ocular involvement. SD-OCT revealed multiple subretinal detachments. Fluorescein and indocyanine green angiography showed triangular non-perfused areas consistent with Amalric triangular choroidal infarction and multiple spots of subretinal leakage. Patients were hospitalized in intensive care unit for treatment with corticosteroids, anticoagulants and plasma exchanges/intravenous immunoglobulins. Full recovery was observed in all cases.
CONCLUSION: The presence of acute choroidal ischemia in patients with antiphospholipid syndrome should alert ophthalmologists to the possibility of CAPS, which is a life-threatening disease. Patients should immediately be referred to a specialist.
PMID:40587879 | DOI:10.1097/ICB.0000000000001779
