Reprod Biomed Online. 2025 Apr 10;51(3):104995. doi: 10.1016/j.rbmo.2025.104995. Online ahead of print.
ABSTRACT
RESEARCH QUESTION: Is a history of pregnancy loss correlated with low age-adapted ovarian reserve in women aged 35 years or younger?
DESIGN: This was a retrospective cohort study.
RESULTS: A total of 931 women aged 35 years or less with anti-Müllerian-hormone (AMH) values measured at presentation to a fertility centre were included in the analysis. The pregnancy loss rate, modelled as pregnancy loss count per previous pregnancy, increased at both ends of the age-normalized AMH z-score, showing a statistically significant increase (odds ratio 0.49, 95% confidence interval 0.25-0.94; P = 0.032) at the lower end (z-score lower than -1.28, 10th percentile) of AMH values.
CONCLUSIONS: Women aged 35 years or less are assumed to have a low risk of aneuploidy as a cause of pregnancy loss. While the association between low ovarian reserve and pregnancy loss in this group is still debated, the findings presented describe a significant association between a history of pregnancy loss in women of 35 years or less and an age-adjusted low ovarian reserve. This calls for assessment of the ovarian reserve in women with pregnancy losses, as an early diagnosis of low ovarian reserve may have far-reaching implications for fertility counselling, especially in an era when women often postpone childbearing.
PMID:40623339 | DOI:10.1016/j.rbmo.2025.104995
