Cureus. 2025 Jun 9;17(6):e85666. doi: 10.7759/cureus.85666. eCollection 2025 Jun.
ABSTRACT
Introduction The COVID-19 pandemic has led to a high number of survivors with persistent symptoms, such as dyspnea, long after recovery. It is important to understand the association between the severity of the initial COVID-19 infection and the persistence of dyspnea to guide patient management and rehabilitation planning. Methods This cross-sectional analysis involved adult patients who had recovered from laboratory-confirmed COVID-19 infection. Patients were stratified into groups by the severity of their acute infection (mild, moderate, severe) based on the WHO Clinical Progression Scale. Persistent dyspnea was measured with a validated dyspnea scale. Statistical analysis was conducted to examine the association between COVID-19 severity and severity of dyspnea, adjusting for potential confounders. Results A total of 385 individuals took part in the study, where 217 people (56%) fell within the 30 to 39 years age bracket, while female participants constituted 52% (200 individuals). The respondents were primarily widowed people who had received secondary education (n = 119, 31%, and n = 118, 31% respectively). A total of 141 participants were current smokers, while 145 participants reported never smoking. Among the study participants, 73 experienced asthma (19%), and hypertension affected 68 individuals (18%). The COVID-19 severity of patients spanned from mild (n = 144, 37%) to critical (n = 78, 20%), and 51% of patients received hospital care (n = 197). Research findings indicated that dyspnea symptoms and advancement in the disease are closely linked (r = 0.521, p < 0.05). People who got oxygen therapy had higher clinical scores than those who did not (p = 0.01). When comparing the ICU patients to other patients, no important differences were noticed (p = 0.05). Recovery was felt very minimally in the results. According to regression analysis, changes in the patient’s clinical condition were highly associated with dyspnea, as shown by a β value of 0.521 and p < 0.001. Conclusion The intensity of COVID-19 infection strongly correlates with both the enduring nature and severity of dyspnea in adults who have recovered from the disease. Post-COVID follow-up and rehabilitation programs require strong evidence behind them to support patients who have experienced severe COVID-19 infections.
PMID:40642682 | PMC:PMC12241829 | DOI:10.7759/cureus.85666
