Arch Gynecol Obstet. 2025 Jul 26. doi: 10.1007/s00404-025-08136-x. Online ahead of print.
ABSTRACT
PURPOSE: In vitro fertilization and embryo transfer (IVF-ET) has become crucial for infertile couples. Previous studies have suggested that multiple ETs are associated with increased risks of preterm birth and low birth weight. The current study aims to investigate this association.
METHODS: PubMed, Cochrane Library, EMBASE, ScienceDirect, and China National Knowledge Infrastructure databases were systematically searched. Network meta-analysis was performed to compare the associations between different numbers of embryo transfers (≥ 2) and the incidence rates of preterm birth and low birth weight. Consistency and inconsistency models were applied to ensure reliability. Frequentist statistical methods used data integration. The surface under the cumulative ranking curve (SUCRA) value was used to rank the risks of preterm birth and low birth weight associated with varying numbers of ETs.
RESULTS: There was a significant difference in the incidence of low birth weight between the 2-ET and 4-ET groups. The 4-ET group had the highest risks for preterm birth and low birth weight.
CONCLUSION: Multiple ETs are associated with increased risks of preterm birth and low birth weight. This study highlights the need for tailored clinical strategies to optimize pregnancy outcomes and mitigate complications.
PMID:40715771 | DOI:10.1007/s00404-025-08136-x
