J Neurosurg Pediatr. 2025 Aug 8:1-9. doi: 10.3171/2025.5.PEDS24548. Online ahead of print.
ABSTRACT
OBJECTIVE: Myelomeningocele (MMC) is a severe neural tube defect frequently associated with vertebral anomalies, including scoliosis and kyphosis, which can significantly impact mobility and quality of life. This study aimed to evaluate the incidence and clinical correlations of scoliosis and other vertebral anomalies in children with MMC.
METHODS: A retrospective analysis of the hospital records of 422 pediatric MMC patients diagnosed between 2013 and 2020 at two tertiary care centers was conducted. Patients were evaluated for scoliosis, kyphosis, hemivertebra, butterfly vertebra, block vertebra, and diastematomyelia using radiographic and MRI findings. The severity of scoliosis was assessed using Cobb angles, and statistical analyses were performed to determine associations between vertebral anomalies.
RESULTS: Scoliosis was identified in 55.9% of patients (mean Cobb angle 35.65°), while kyphosis was present in 41.2%. The presence of hemivertebra and butterfly vertebra was strongly associated with scoliosis progression. Additionally, patients with split cord malformations exhibited a higher incidence of scoliosis and kyphosis. Age was found to be a key factor in scoliosis severity, with curve progression observed over time.
CONCLUSIONS: Scoliosis and other vertebral anomalies are highly prevalent in MMC patients, necessitating early diagnosis and multidisciplinary management. These findings underscore the importance of long-term monitoring and individualized treatment approaches to optimize spinal health and functional outcomes.
PMID:40779802 | DOI:10.3171/2025.5.PEDS24548
