Synergistic effects of PM2.5 components and ozone exposure on lung function in young adults: A cohort study in Shandong, China

Ecotoxicol Environ Saf. 2025 Aug 11;303:118842. doi: 10.1016/j.ecoenv.2025.118842. Online ahead of print.

ABSTRACT

Exposure to fine particulate matter (PM_2.5) components and ozone (O₃) is associated with reduced lung function. This study aimed to examine the interaction effects of PM_2.5 components and O₃ on lung function in young adults. A cohort study involving 1697 participants was conducted in Shandong Province, China from September 2019 to November 2020. Pollutant data were obtained from the China High Air Pollutants (CHAP) dataset and the Tracking Air Pollution in China (TAP) dataset. Forced Vital Capacity (FVC), first-second forceful expiratory volume (FEV_1.0), peak expiratory flow rate (PEF) and 50 % forceful expiratory flow rate (FEF_{50 %}) were used as lung function indices. A linear mixed-effects model was employed to evaluate the impact of PM_2.5 components and its interaction effects with O₃ on lung function. Each 1 μg/m³ increase in black carbon (BC) concentration was significantly associated with 0.4027 L/s decrease in PEF (95 % confidence interval (CI): 0.2420 L/s, 0.5634 L/s). Increases in other PM_2.5 components were also associated with various reduced lung function indices. Notably, the interaction term for BC and O₃ was significantly associated with reduced PEF (-0.0243, 95 % CI: -0.0472, -0.0014). Synergistic effects between PM_2.5 components [organic matter (OM), nitrate (NO₃^–)] and O₃ adversely impacted lung function. A more proactive policy should be adopted to address the synergistic effects of air pollution.

PMID:40795423 | DOI:10.1016/j.ecoenv.2025.118842