Clinics (Sao Paulo). 2025 Aug 21;80:100731. doi: 10.1016/j.clinsp.2025.100731. Online ahead of print.
ABSTRACT
OBJECTIVE: To investigate the effects of Bifid Triple Viable (BTV) capsule on inflammatory factors and intestinal barrier function in children with abdominal infection.
METHODS: 100 children with abdominal infections were selected. The control group (50 cases) was given conventional treatment, and the observation group (50 cases) was given BTV capsule treatment on the basis of the control group. The remission of clinical symptoms was compared, and the changes in inflammatory factors, intestinal mucosal barrier function indices, intestinal flora number, and immune function indices were observed, and the occurrence of adverse reactions during treatment was statistically analyzed.
RESULTS: The time of vomiting remission, fever remission, stool recovery, and abdominal pain remission in the observation group was shorter than those in the control group. IL-6, CRP, and TNF-α in the observation group were lower and IFN-γ was higher compared with the control group. DAO, D-lactic acid, LPS, Occludin, and ZO-1 in the observation group were lower than those in the control group. The quantity of bifidobacterium, acidobacteria, and clostridium leptum in the observation group was higher than that in the control group, and the quantity of enteric bacillus and enterococcus was lower. IgA and IgG levels in the observation group were lower than those in the control group after treatment.
CONCLUSION: BTV capsule can reduce the local inflammatory response of abdominal infection and improve the intestinal mucosal barrier function and immune function.
PMID:40845476 | DOI:10.1016/j.clinsp.2025.100731
