PLoS One. 2025 Sep 4;20(9):e0330998. doi: 10.1371/journal.pone.0330998. eCollection 2025.
ABSTRACT
BACKGROUND: The consumption of sorghum-based foods has been associated with reduced postprandial blood glucose levels and increased satiety in previous studies. Sorghum’s low glycemic index, high fiber content, and rich profile of bioactive compounds may contribute to improved health outcomes. Nutritional strategies incorporating sorghum could serve as a valuable tool for the prevention of diabetes, obesity, as well as other non-communicable diseases.
PURPOSE: To identify and evaluate the evidence on the effectiveness of the sorghum-based foods in modulating blood glucose levels and promoting satiety in adults.
METHODS AND EXPECTED OUTPUTS: This systematic review protocol was developed in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) guidelines. We will include randomized controlled trials (RCTs) and non-randomized controlled trials (NRCTs) published through February 2025 that assess the effects of sorghum-based food consumption. Qualitative studies, guidelines, and reviews will be excluded. Six electronic databases-MEDLINE/PubMed, Embase, Cochrane Central Register of Controlled Trials, Web of Science, Scopus, and ScienceDirect-will be systematically searched. Additional sources will include ClinicalTrials.gov, The British Library, Google Scholar, International Diabetes Federation, and American Diabetes Association (ADA). No restrictions on language or publication date will be applied. Two independent reviewers will perform study selection, data extraction, and risk of bias assessment according to the study design. A qualitative synthesis will be presented. Statistical heterogeneity will be assessed using the I² statistic. If appropriate, a meta-analysis will be conducted using a random-effects model.
EXPECTED OUTCOMES: To the best of our knowledge, this will be the first systematic review to specifically address the impact of sorghum-based food consumption on glycemic response and satiety. The findings are expected to provide robust evidence to inform future research and support nutritional strategies involving sorghum-based products for health promotion.
PROSPERO REGISTRATION ID: CRD42023431520.
PMID:40906791 | DOI:10.1371/journal.pone.0330998
