Lasers Med Sci. 2025 Sep 20;40(1):376. doi: 10.1007/s10103-025-04650-1.
ABSTRACT
The introduction of diode semiconductor lasers operating in the infrared spectrum has significantly advanced dental practice, elevating it to a new level of clinical efficiency. These technologies enable treatment methods that markedly reduce patient recovery time. Laser wavelengths of 810 ± 10 nm and 980 ± 10 nm are widely utilized in laser surgery and photobiomodulation. Of growing interest is the potential use of laser irradiation at a wavelength of 445 nm for photobiomodulation of oral mucosal tissues in cases of periodontal diseases and stomatitis. Using laser Doppler flowmetry, we demonstrated the effectiveness of non-ablative blue laser application to the gingival area in 20 healthy volunteers aged 22.9 ± 0.8 years. A statistical analysis was conducted to assess gingival microcirculation parameters, including peripheral blood flow, peripheral lymphatic flow, tissue fluorescence amplitude at 460 nm (NADH coenzyme), and at 515 nm (FAD coenzyme). Oxidative metabolism index was calculated using a specific formula. Following a 1-minute low-level laser irradiation session, a statistically significant average increase of 3.07 perfusion units in microcirculation was observed. Lymphatic perfusion values decreased by an average of 0.04 perfusion units. The oxidative metabolism index increased by an average of 0.16 perfusion units post-procedure. The observed enhancement in blood flow velocity and oxidative metabolism index in gingival tissues after exposure to 445 nm wavelength laser irradiation at 0.1 W confirms the therapeutic potential of blue laser technology.
PMID:40974420 | DOI:10.1007/s10103-025-04650-1
