IEEE Trans Neural Syst Rehabil Eng. 2025 Sep 29;PP. doi: 10.1109/TNSRE.2025.3615417. Online ahead of print.
ABSTRACT
Chronic low back pain (LBP) significantly impairs daily functional movements. Persistent pain may trigger alterations in neuromuscular control, particularly muscle coordination. However, muscle synergy patterns during specific functional tasks in patients with LBP remain unclear. We recruited 36 participants, including 18 patients with chronic LBP (the LBP group) and 18 healthy participants (the control group). Surface electromyography signals were recorded from ten trunk and lower-limb muscles during three common functional tasks: sit-to-stand, trunk flexion, and lifting. Muscle synergies were extracted via non-negative matrix factorization. Cosine similarity analysis and statistical parametric mapping were applied to evaluate spatial (motor modules) and temporal (motor primitives) differences between groups. Compared to the control group, participants with chronic LBP exhibited a reduced number of muscle synergies during sit-to-stand, indicating adaptive reorganization of motor modules. Although spatial muscle synergy structures were largely conserved between groups, significant temporal differences emerged in trunk flexion, particularly during eccentric phases. Patients with LBP showed prolonged and temporally shifted activation of spinal extensors and hip-pelvic stabilizers, suggesting compensatory mechanisms to mitigate spinal loading. Muscle contribution patterns during lifting tasks also differed significantly between groups, despite similar temporal activation. In conclusion, patients with chronic LBP demonstrate distinct muscle synergy adaptations characterized by reduced complexity, altered timing during eccentric trunk movements, and modified lower-limb recruitment strategies. Trunk flexion emerged as a particularly sensitive task for identifying neuromuscular deficits in LBP. These findings provide targeted insights for clinical rehabilitation, emphasizing eccentric trunk control, motor control timing, and lower-limb muscle retraining.
PMID:41021946 | DOI:10.1109/TNSRE.2025.3615417
