Support Care Cancer. 2025 Oct 10;33(11):927. doi: 10.1007/s00520-025-10012-y.
ABSTRACT
PURPOSE: To investigate the current status of CRF and identify its influencing factors in patients undergoing chemotherapy for gastric cancer.
METHODS: A total of 525 patients receiving chemotherapy for gastric cancer were recruited from a tertiary general hospital in China. Data were collected using a set of standardized questionnaires. Stepwise multiple linear regression was applied to determine the impact of variables that were statistically significant (P < 0.05) in independent sample t tests, one-way ANOVA, and correlation analyses on fatigue levels. All statistical tests were two-sided, with a significance level set at α = 0.05.
RESULTS: The median (interquartile range) scores for total CRF, physical fatigue, emotional fatigue, and cognitive fatigue were 21.00 (15.00-27.00), 8.00 (4.00-12.00), 9.00 (7.00-11.00), and 4.00 (1.00-6.00), respectively. Overall, 57.2% of patients experienced moderate to severe fatigue. Multivariate analysis showed that female gender, nutritional risk status, poor sleep status, depression, and pain were significantly associated with higher CRF in patients undergoing chemotherapy for gastric cancer, together explaining 31.6% of the total variance.
CONCLUSION: CRF is highly prevalent among patients with gastric cancer and is influenced by multiple factors. These findings provide scientific evidence for the early identification of high-risk groups and the development of personalized intervention programs.
PMID:41073814 | DOI:10.1007/s00520-025-10012-y
