JNCI Cancer Spectr. 2025 Oct 15:pkaf098. doi: 10.1093/jncics/pkaf098. Online ahead of print.
ABSTRACT
BACKGROUND: Diagnosis, treatment, and outcomes of colon cancer in the U.S. differs between patients younger than age 50 (early-onset colon cancer, EOCC) and those age 50 or older (average-onset, AOCC) and may be impacted by access to care. Less is known about surgical quality and post-operative outcomes between patients with EOCC and AOCC. This study aimed to compare patients with EOCC and AOCC in surgical aspects and 30-day postoperative complications and readmissions in the Military Health System.
METHODS: The cohort included patients diagnosed with stage I-III colon adenocarcinoma between 2001 and 2014 who received surgery. Poisson regression with robust standard errors estimated the adjusted risk ratios (ARRs) and 95% confidence intervals (CIs) in association with age at diagnosis for the outcomes.
RESULTS: Among 333 patients with EOCC and 1369 patients with AOCC, there were no statistically significant differences in surgical delay, positive margins, or inadequate lymphadenectomy. Patients with EOCC had statistically higher adjusted 30-day risk of any complication (ARR = 1.31, 95% CI = 1.05, 1.63), inclusive of general surgical (ARR = 1.64, 95% CI = 1.14, 2.38) and gastrointestinal (ARR = 1.29, 95% CI = 1.00, 1.65) complications, relative to patients with AOCC. There was no statistically significant difference in 30-dayreadmission for patients with EOCC (ARR = 1.30, 95% CI = 0.84, 202) compared to patients with AOCC.
CONCLUSION: In the Military Health System, patients with EOCC had higher adjusted 30-day risk of complications following surgery compared to patients with AOCC. This finding may have implications for care delivery and postoperative management of patients with EOCC to reduce complication burden and achieve optimal outcomes.
PMID:41092401 | DOI:10.1093/jncics/pkaf098
