Neurol Res. 2025 Nov 2:1-8. doi: 10.1080/01616412.2025.2583441. Online ahead of print.
ABSTRACT
BACKGROUND: Intracranial hemorrhage (ICH) prevalence is increasing, yet its genetic risk factors and micronutrient associations remain unclear.
METHODS: We performed univariable and multivariable Mendelian randomization (MR) analyses using 15 micronutrients derived from genome-wide association study (GWAS) data to assess their relationship with ICH risk.
RESULTS: Univariable MR analysis suggested that genetically predicted vitamin B6 [odds ratio (OR) = 0.6 (95% CI, 0.38 to 0.96), p = 0.033] and vitamin E [OR = 0.49 (95% CI, 0.33 to 0.73), p < 0.001] were potentially associated with the risk of ICH. Other micronutrients did not exhibit statistically significant associations with ICH in this analysis. Furthermore, multivariable MR analysis revealed significant causal relationship between vitamin E and ICH [OR = 0.514 (95% CI, 0.312 to 0.845), p = 0.009].
CONCLUSION: Vitamin E levels are significantly associated with reduced ICH risk, indicating its potential as a preventative agent. Further research is needed to explore this relationship fully.
PMID:41176655 | DOI:10.1080/01616412.2025.2583441
