Biomed Eng Online. 2025 Nov 11;24(1):134. doi: 10.1186/s12938-025-01437-x.
ABSTRACT
OBJECTIVE: To systematically review and compare the clinical efficacy and impact on fertility function between laparoscopic surgery and methotrexate treatment for tubal pregnancy.
METHODS: Five English databases and four Chinese databases were systematically searched from the database establishment to January 31, 2024, and a meta-analysis was conducted using Review Manager 5.3.
RESULTS: Ten articles were included, with a total of 1,034 study patients. The meta-analysis showed that compared with a single intramuscular injection of methotrexate, laparoscopic surgery for tubal pregnancy was associated with a significantly higher tubal patency rate [OR = 2.47, 95% CI 1.72-3.53, P < 0.001]; and a significantly higher spontaneous pregnancy rate [OR = 2.10, 95% CI 1.28-3.46, P = 0.003]; and a shorter time for serum HCG levels to return to normal [MD = -7.10, 95% CI – 7.84-6.36, P < 0.001]. However, there was no statistically significant difference in treatment success rate between the two treatment methods [OR = 1.88, 95% CI 0.53-6.69, P = 0.33], and no statistically significant difference in recurrent EP rate [OR = 1.09, 95% CI 0.41-2.87, P = 0.87].
CONCLUSION: Compared with a single intramuscular injection of methotrexate, laparoscopic surgery for tubal pregnancy is associated with better fertility function in the future, while the difference in clinical efficacy needs further exploration.
PMID:41219963 | DOI:10.1186/s12938-025-01437-x
