Eur J Clin Microbiol Infect Dis. 2025 Nov 15. doi: 10.1007/s10096-025-05355-7. Online ahead of print.
ABSTRACT
OBJECTIVE: To investigate the pathogens and clinical characteristics of necrotizing pneumonia (NP) in our hospital from January 2019 to June 2025.
METHODS: We retrospectively analyzed the clinical data of children with NP. Patients were divided into a single- bronchoalveolar lavage (BAL) group and a multiple-BAL group. Pathogens and clinical characteristics were compared between the two groups.
RESULTS: This study included 365 patients with NP, 193 of whom were males. The incidence of NP significantly increased in 2023-2024. The pathogen identification rate was 98.36%, with Mycoplasma pneumoniae (MP) being the most commonly pathogen (91.00%). There were 138 cases of mixed infection and 227 cases of single infection. The 335 cases underwent BAL, with 139 cases assigned to the single-BAL group. Follow-up within 6 months after discharge was conducted for 238 patients, and the majority exhibited a favorable prognosis. No statistical differences were observed between the two groups regarding gender, age, time from onset to diagnosis, or duration of fever. However, a significant difference was noted in the length of hospital stay (P < 0.05). The infection rate of MP in the single-BAL group was lower than that in the multiple-BAL group (P < 0.05).
CONCLUSION: The incidence of NP significantly increased in 2023-2024, with MP as the predominant pathogen. Children with NP present with severe clinical symptoms, a prolonged disease course, and significantly elevated inflammatory markers. Most NP patients have a favorable prognosis. Patients requiring multiple BAL procedures demonstrate a higher MP infection rate.
PMID:41240235 | DOI:10.1007/s10096-025-05355-7
