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Nevin Manimala Statistics

Creating an Atlas of Growing Skull Templates in Vestibular Orientation for Analysis of Craniofacial Malformations

J Craniofac Surg. 2025 Nov 17. doi: 10.1097/SCS.0000000000012132. Online ahead of print.

ABSTRACT

The large availability of high-resolution CT scans leads to the collection of vast amounts of 3D volumetric data on craniofacial malformations, as well as on normal patients of all ages. A precise analysis of deformities occurring in craniofacial malformations can be gained from comparison with a normal skull. Doing such a comparison with a single case may be considered a bias. We have utilized a function in the 3DSlicer application, known as DeCA (Dense Correspondence Analysis), which calculates a statistical mean 3D model from a set of models. From 184 CT scans, allegedly normal. We created 19 models named “Skull Atlas ###-###d” (###-### for the range of age in days). The statistical value of those models is verified using another function in 3Dslicer, named GPA, which draws equiprobable ellipses for the markups. We explain how to superpose the reference Skull Atlas with the skull of interest. We used the vestibular orientation for aligning the models.

PMID:41248433 | DOI:10.1097/SCS.0000000000012132

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