Per Med. 2025 Nov 21:1-9. doi: 10.1080/17410541.2025.2592528. Online ahead of print.
ABSTRACT
BACKGROUND: Urinary bladder cancer (UBC), the tenth most common globally with a male predominance, has its risk factors like smoking and single nucleotide polymorphisms (SNPs), yet the MYC gene’s role, especially the rs9642880 GT/TT polymorphism on chromosome 8q24.21, in cancer susceptibility is underexplored.
METHODS: We searched in Medline, Scopus and Web of Science databases for relevant studies. Odds ratios (OR) with 95% confidence intervals (CIs) were computed using DerSimonian and Laird random-effect models. Heterogeneity was assessed using I2 statistics. Statistical analyses were performed using R, version 4.4.2.
RESULTS: Data from 53,957 subjects was analyzed, including 8,002 UBC patients and 45,955 controls, with median age ranging from 44.5 to 68.7 years. We found significant association between the rs9642880 GT/TT polymorphism and increased UBC risk (OR 1.249, 95% CI 1.188-1.297, p < 0.001). This association was consistent across American (OR 1.43 95% CI 1.20-1.70), Asian (OR 1.25 95% CI 1.17-1.34), and Caucasian (OR 1.21 95% CI 1.13-1.29) ethnic groups, with low heterogeneity (I2 = 0%). Subgroup analyses by genotyping method and source of control further supported these results.
CONCLUSION: This meta-analysis provides robust evidence that the T allele of the rs9642880 polymorphism in the MYC gene significantly increases susceptibility to UBC across Asian, American, and Caucasian populations.
PMID:41268746 | DOI:10.1080/17410541.2025.2592528
