Diabetes Metab Syndr. 2025 Nov 19;19(10):103328. doi: 10.1016/j.dsx.2025.103328. Online ahead of print.
ABSTRACT
BACKGROUND AND AIMS: This systematic review and meta-analysis was conducted to evaluate the effects of artichoke supplementation on cardiometabolic health markers in adults.
METHODS: A comprehensive literature search of PubMed, Scopus, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials was conducted up to September 2024.
RESULTS: Artichoke supplementation significantly reduced body mass index (WMD = -0.51 kg/m2, 95 % CI: 0.93 to -0.09) and waist circumference (WMD = -1.21 cm, 95 % CI: 2.24 to -0.17), while its effects on body weight and hip circumference were not statistically significant. Blood pressure outcomes revealed significant reductions in both systolic (WMD = -2.49 mmHg, 95 % CI: 4.33 to -0.65) and diastolic (WMD = -1.53 mmHg, 95 % CI: 3.01 to -0.05) pressures. Significant lipid profile improvements were observed in total cholesterol (WMD = -12.29 mg/dL, 95 % CI: 19.92 to -4.65), low-density lipoprotein cholesterol (WMD = -10.31 mg/dL, 95 % CI: 18.57 to -2.04), and triglycerides (WMD = -12.85 mg/dL, 95 % CI: 24.77 to -0.93), with no significant effect on high-density lipoprotein cholesterol. Regarding glycemic indices, insulin (WMD = -1.83 mU/L, 95 % CI: 3.33 to -0.32) and homeostatic model assessment for insulin resistance (WMD = -0.92, 95 % CI: 1.33 to -0.51) were significantly reduced, whereas fasting blood glucose and HbA1c were unaffected. Among liver function markers, alanine aminotransferase (WMD = -8.47 U/L, 95 % CI: 14.71 to -2.23) and alkaline phosphatase (WMD = -7.86 U/L, 95 % CI: 15.26 to -0.45) were significantly reduced, while aspartate aminotransferase showed a borderline non-significant effect. No significant change was observed in creatinine levels.
CONCLUSION: Artichoke supplementation may offer modest but significant improvements in several cardiometabolic risk markers.
PMID:41270328 | DOI:10.1016/j.dsx.2025.103328
