Cancer Causes Control. 2026 Jan 17;37(2):31. doi: 10.1007/s10552-025-02119-8.
ABSTRACT
BACKGROUND: Psychiatric comorbidities are common in patients with Hodgkin lymphoma (HL) and may influence treatment adherence and survival outcomes. This study aimed to evaluate the impact of psychiatric disorders on overall survival and treatment adherence in HL patients.
METHODS: A retrospective cohort study was conducted including 139 HL patients treated at the General Hospital of Mexico “Dr Eduardo Liceaga.” Clinical, demographic, and psychiatric data were collected. Overall survival was analyzed using Kaplan-Meier curves and Cox proportional hazards models adjusted for Ann Arbor stage, treatment adherence, and psychiatric disorders. Treatment adherence was assessed, and its association with survival was explored using time-varying hazard ratios.
FINDINGS: Among 139 patients, those with psychiatric disorders exhibited significantly worse overall survival (HR 6.80, 95% CI 1.32-34.95, p = 0.022). Adherence to treatment was independently associated with improved survival (HR 0.05, 95% CI 0.02-0.16, p < 0.001). Time-varying analysis showed the highest hazard ratio for psychiatric disorders during the early follow-up period.
CONCLUSION: Psychiatric disorders are independently associated with poorer overall survival in patients with Hodgkin lymphoma, partly mediated by reduced treatment adherence. Early recognition and integrated psychosocial interventions may improve treatment continuity and survival outcomes.
PMID:41546839 | DOI:10.1007/s10552-025-02119-8
