Eurasian J Med. 2025 Dec 17;57(4):1-6. doi: 10.5152/eurasianjmed.2025.251130.
ABSTRACT
BACKGROUND: Chronic sinusitis with nasal polyp (CSwNP) is a common disease that can be recurrent at a rate of up to 40-60%. Various markers are being investigated to determine the prognosis in the treatment of nasal polyp (NP). Resistin is an inflammatory cytokine that may play a role in the etiology of NP. The aim of the study was to determine the resistin expression in NP epithelium and compare the resistin expression both in normal respiratory epithelium and NP epithelium.
METHODS: The patients who were operated for CSwNP were included as the study group, and the patients without nasal pathology were included as the control group. The operation specimens of the patients were stained with immunohistochemical methods, and the expression of resistin was examined and scored.
RESULTS: Specimens of the 115 patients were included in the study. It was determined that the frequency of asthma (P =. 006), resistin staining percentage (P = .004), resistin staining score (P = .026) and eosinophil percentage (P < .001) were statistically significantly higher in the NP patients than in the control group.
CONCLUSION: It was observed that resistin expression was higher in NP epithelium than in normal respiratory epithelium, and this is the first known study, to the authors’ knowledge, on this subject. Cite this article as: Torun MT, Yılmaz GT. Analysis of resistin expression in nasal polyp tissue. Eurasian J Med. 2025, 57(4), 1130, doi: 10.5152/eurasianjmed.2025.251130.
PMID:41578827 | DOI:10.5152/eurasianjmed.2025.251130
