Bioinformatics. 2026 Jan 29:btag041. doi: 10.1093/bioinformatics/btag041. Online ahead of print.
ABSTRACT
SUMMARY: DNAvi is a Python-based tool for rapid grouped analysis and visualization of cell-free DNA fragment size profiles directly from electrophoresis data, overcoming the need for sequencing in basic fragmentomic screenings. It enables normalization, statistical comparison, and publication-ready plotting of multiple samples, supporting quality control and exploratory fragmentomics in clinical and research workflows.
AVAILABILITY AND IMPLEMENTATION: DNAvi is implemented in Python and freely available on GitHub at https://github.com/anjahess/DNAvi under a GNU General Public License v3.0, along with source code, documentation, and examples. An archived version is available under https://doi.org/10.5281/zenodo.18097730.
SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
PMID:41609423 | DOI:10.1093/bioinformatics/btag041
