Ann Gen Psychiatry. 2026 Feb 3. doi: 10.1186/s12991-025-00622-5. Online ahead of print.
ABSTRACT
BACKGROUND: This study aimed to examine if individuals diagnosed with dissociative disorder (DD) are at a higher risk of suicidal acts compared to individuals without DD.
METHODS: We conducted a matched cohort study by examining electronic health records of patients admitted to Hong Kong public hospitals between January 1, 1993, through December 31, 2022. The study included 716 patients with DD and a matched comparison cohort of 716 individuals. Participants were tracked until they either received a diagnosis of suicidal acts, died from other causes, or until the end of 2023, whichever happened first. Cox proportional hazards regression models were applied to determine the risk of suicidal acts following DD onset.
RESULTS: During the 30-year study period, 87 individuals (12.2%) in the DD cohort and 29 individuals (4.1%) in the comparison cohort exhibited suicidal acts, with the difference being statistically significant (χ2 = 25.21, p = 0.0001). The incidence rates of suicidal acts were 86.7 and 27.3 per 10,000 person-years for the DD and comparison cohorts, respectively. After adjustment, the hazard ratio for suicidal acts in the DD cohort compared with the comparison cohort was 1.89 (95% confidence interval, 1.17-3.06).
CONCLUSIONS: DD is linked to a heightened risk of suicidal acts. Future research is required to replicate these findings and to more comprehensively identify the specific risk factors contributing to suicidal acts in this patient population.
PMID:41634844 | DOI:10.1186/s12991-025-00622-5
