Eur J Med Res. 2026 Feb 14. doi: 10.1186/s40001-026-04053-0. Online ahead of print.
ABSTRACT
INTRODUCTION: Idiopathic Granulomatous Mastitis (IGM) is a chronic inflammatory disease that affects women of childbearing age and is prone to recurrence. The M-score can be used to measure the severity of symptoms and assess the response to treatment in IGM patients. The aim of this study is to investigate the effect of the initial M-score on the recurrence of the disease in IGM patients.
MATERIAL AND METHODS: A total of 90 patients who were clinically and histopathologically diagnosed with IGM were included in the present study. The patient data were analyzed retrospectively. The M-score, which provides more objective data, was used to evaluate the severity of symptoms. Disease recurrence rates were compared with the initial M-score.
RESULTS: The recurrence rate in patients with abscesses was higher (93.18%) than in patients without abscesses (60.87%) (p < 0.001). No statistically significant differences were found when analysing the recurrence rates in patients who underwent surgery (p = 0.518). When analysing recurrence rates according to initial M-score values, patients with an initial M-score of ≥ 5 had a significantly higher recurrence rate (98.4%) than patients with an initial M-score < 5 (24%) (p < 0.001).
CONCLUSION: The treatment of IGM patients depends on the patient’s symptoms. For this reason, a scoring system is needed to define the symptoms and interpret the response to treatment more objectively. The M-score is at a level that can meet this need. In the present study, the recurrence rate was found to be higher in patients with an initial M-score ≥ 5 than in patients with an M-score < 5, which leads us to the idea of initiating more aggressive treatment than observation or mono-treatment in patients with high M-scores at the time of presentation.
PMID:41691333 | DOI:10.1186/s40001-026-04053-0
