Am J Audiol. 2026 Feb 24:1-15. doi: 10.1044/2025_AJA-25-00241. Online ahead of print.
ABSTRACT
PURPOSE: Cochlear synaptopathy, the loss of the synapses between the inner hair cells and their auditory nerve fiber targets, is expected to be a common type of auditory deficit resulting from noise exposure or aging. Unfortunately, there is currently no means for diagnosing cochlear synaptopathy or other forms of cochlear deafferentation. Wideband middle ear muscle reflexes (MEMRs) have been proposed as a potential diagnostic indicator of cochlear deafferentation, but we lack normative ranges for MEMR magnitude. The objective of this study was to develop normative ranges for wideband MEMR magnitude that can be used to identify patients with abnormally weak MEMRs.
METHOD: Normative ranges were generated for ipsilateral and contralateral wideband MEMR magnitude in a population at low risk for cochlear synaptopathy due to young age, normal hearing thresholds, and minimal noise exposure history. The normative ranges were statistically adjusted for average distortion product otoacoustic emission (DPOAE) levels to account for possible impacts of outer hair cell dysfunction. To evaluate the ability of the normative ranges to differentiate between populations at low versus high risk of synaptopathy, measurements were also collected from military Veterans with normal hearing thresholds who reported at least one of the auditory complaints predicted to result from synaptopathy-tinnitus, speech perception in noise difficulty, or decreased sound tolerance.
RESULTS: For individuals with poorer DPOAEs, it is not possible to fall below the lower bounds of the wideband MEMR normative ranges. For individuals with more robust DPOAEs, the lower bounds are very close to an MEMR magnitude indicating an absent reflex. Few individuals from the high-risk sample fell below the normative ranges, suggesting that these normative ranges do not identify significant cochlear deafferentation as expected.
CONCLUSION: Wideband MEMR magnitude normative ranges will not be effective as a stand-alone indicator of cochlear deafferentation.
PMID:41734241 | DOI:10.1044/2025_AJA-25-00241
