Cancer Sci. 2026 Mar 6. doi: 10.1111/cas.70357. Online ahead of print.
ABSTRACT
Colorectal cancer (CRC) is one of the most common types of invasive cancer worldwide, which has the characteristics of poor curative effect and poor prognosis. Increasing evidence suggests that hyperactivated glucose uptake has become a key marker of cancer. This metabolic reprogramming is called the “Warburg effect” or aerobic glycolysis, which provides abundant energy, nutrient, and redox requirements to support malignant growth and metastasis of cancer cells. In this review, we review the role of glucose metabolism in colorectal cancer initiation, growth, and metastasis, discussing current therapeutic strategies aimed at repairing impaired glucose metabolism in CRC.
PMID:41793098 | DOI:10.1111/cas.70357
