J Epidemiol. 2026 Mar 7. doi: 10.2188/jea.JE20250668. Online ahead of print.
ABSTRACT
Age-standardization is a key statistical method used in health statistics to adjust rates such as mortality or incidence, enabling comparisons across populations or time points with different age structures. This review traces its historical development, global and country-specific practices, and future directions. The method dates back to the 19th century, with major adoption in the 20th century through the Segi and Doll’s World Standard Population. While the World Health Organization (WHO) introduced an updated standard in 2000, the International Agency for Research on Cancer (IARC) continues to use the Segi and Doll’s standard in the Cancer Incidence in Five Continents series, prioritizing consistency and comparability in long-term cancer surveillance. Case studies from the IARC, the United States (U.S.), Japan, and the Republic of Korea (Korea) illustrate different responses to changing demographics. The U.S. adopted the 2000 standard with expanded age detail for the elderly population. Japan introduced the 2015 Japan Standard Population to account for its rapidly aging society, though regional data limitations presented challenges. Korea, experiencing one of the fastest aging transitions globally, updated to a 2020 standard for more accurate national and sub-national reporting. The review also emphasizes that age-standardization can obscure important age-specific trends. Methods like Joinpoint clustering help detect divergent trends by age groups. Looking forward, age-standardization remains essential amid global demographic shifts. However, updates of standard populations must balance improved relevance with the need for continuity and robust data. International coordination and digital tools will support more flexible and transparent health statistics in the future.
PMID:41795926 | DOI:10.2188/jea.JE20250668
