J Epidemiol Glob Health. 2026 Mar 29. doi: 10.1007/s44197-026-00545-8. Online ahead of print.
ABSTRACT
BACKGROUND: Non-unions (NU) after fractures, especially in cases with the need of surgical intervention, represent one of the most severe complications in traumatology. As previous studies estimate post-fracture NU risk between 2% and 10% data inconsistencies persist. In particular, the data on the influence of different anatomical regions, age and sex on fracture associated NU is scarce. Therefore, this study aims to provide a comprehensive descriptively assessment of the ratio of surgically treated tibia and femur NU to tibia and femur fractures based on a nationwide dataset, with a specific focus on differences across anatomical regions.
METHODS: This retrospective, population-based, cross-sectional analysis of the German InEK database (2019-2023) was conducted, including 888,442 fractures and 3,017 NU cases. The study focused on ICD- (International Statistical Classification of Diseases and Related Health Problems-) coded diagnoses of femur and tibia NU and their associated fractures. To enhance precision, fracture and NU sites were grouped according to different anatomical regions assessed by documented OPS- (Operation and Procedure Classification System) codes. Subgroup analyses were performed for age and sex.
RESULTS: Surgically treated femoral shaft NU had the highest incidence (0.18 cases per 100,000 residents and year), followed closely by tibial shaft NU (0.16). The highest NU/100-fractures ratio was observed in tibial shaft (1.277), followed by distal tibia (1.095) and distal femur (0.996). Across all localisations, men had clearly higher NU/100-fractures ratios than women. NU/100-fractures ratios also varied with age, with highest ratio in the economically active population, followed by a generally decline in older patients.
CONCLUSION: This nationwide database study indicates that surgically treated NU/fracture ratios of femur and tibia are generally low. The proportion of NU to fracture differ between different anatomical regions. In general, proximal localisations showed lower NU/100-fractures ratios than distal localisations within the femur and in comparison of femur and tibia. Independently of the anatomical localisation men had a higher NU/100-fractures ratio than women. As highest NU/100-fractures ratios were detected in the economically active population, this highlights the substantial socioeconomic burden associated with this condition.
PMID:41904778 | DOI:10.1007/s44197-026-00545-8
