J Hum Hypertens. 2026 Apr 7. doi: 10.1038/s41371-026-01145-6. Online ahead of print.
ABSTRACT
While mobile health shows potential in hypertension treatment, its effectiveness for middle-aged and older adults is unclear. The primary objective of this study was to evaluate the effects of mobile health interventions on blood pressure outcomes in this group of population; the secondary objective was to examine their impact on patients’ self-management and to identify potential influencing factors. PubMed, Cochrane Library, Embase, Web of Science, and Scopus databases were searched until March 2025. The included studies were randomized controlled trials (RCTs) evaluating the effects of mobile health interventions on blood pressure and self-management outcomes. Meta-analysis used Review Manager 5.3 and Stata 17.0, with quality assessed by Cochrane ROB2.0. Fourteen RCTs with 6292 patients were included. Compared with traditional care, mobile health interventions demonstrated significant advantages in improving systolic blood pressure, diastolic blood pressure, blood pressure control rates, treatment adherence, hypertension-related knowledge, and quality of life, while no statistically significant effect was observed on hypertension self-efficacy. Subgroup analyses indicated that, aside from a borderline between-subgroup difference in diastolic blood pressure stratified by intervention type (P = 0.05), the blood pressure-lowering effects of mobile health interventions were generally consistent across various age groups and intervention modalities. In summary, mobile health interventions can significantly improve clinical outcomes and self-management levels among patients aged ≥ 45 years with hypertension; however, their effects on hypertension self-efficacy remain limited. Further long-term, high-quality studies are needed.
PMID:41946822 | DOI:10.1038/s41371-026-01145-6
