J Integr Neurosci. 2026 Apr 21;25(4):47468. doi: 10.31083/JIN47468.
ABSTRACT
BACKGROUND: Depression affects 28.4% of middle-aged and older adults globally, exacerbating functional decline, mortality, and healthcare burdens. Physical activity mitigates depression through neurobiological and psychosocial pathways, although efficacy varies significantly by gender. Current evidence lacks clarity regarding optimal physical activity intensity and interventions. This study aimed to identify the physical activity patterns most strongly associated with depression and to derive potential intervention targets for middle-aged and older Chinese adults.
METHODS: The data from 3739 participants in the 2020 China Health and Retirement Longitudinal Study were analyzed. Gaussian graphical models were adopted to recognize core and bridge symptoms within physical activity-depression networks across genders. Subsequently, computer-simulated interventions were conducted to determine the optimal targets for reducing depressive symptoms by gender.
RESULTS: Both male and female networks identified “depressed” as the central symptom. However, the bridge symptoms differed: males exhibited a bridge role for “days with moderate physical activity per week”, whereas females showed this for “duration of moderate physical activity per day”. Network comparison test revealed significant gender differences in edge weights (p = 0.007), with 14 edges being statistically significant. Simulation interventions consistently pinpointed “depressed” and “stuck” as effective targets for intervention across genders.
CONCLUSIONS: Moderate physical activity most strongly correlated with depression. For men, interventions might prioritize increasing the regularity per week with moderate physical activity to prevent depression, whereas for women, focusing on the duration per day of such activity could be a promising target.
PMID:42052763 | DOI:10.31083/JIN47468
