Brain Inform. 2026 May 11. doi: 10.1186/s40708-026-00302-4. Online ahead of print.
ABSTRACT
Accurate detection of Mild Cognitive Impairment (MCI) is critical for timely intervention and for slowing progression to Alzheimer’s disease. Electroencephalography (EEG) offers a non-invasive and cost-effective measure of brain activity; however, its complex, non-linear dynamics limit conventional analysis. We propose a CNN-Res-SE-BiLSTM-BiGRU framework for the automated detection of MCI directly from raw EEG. Convolutional and residual blocks capture local temporal structure, bidirectional recurrent layers model long-range dependencies, and Squeeze-and-Excitation (SE) modules provide channel-wise attention. Predicted probabilities are calibrated using temperature scaling, and operating thresholds are selected on the validation set using Youden’s J statistic. The model is evaluated using five-fold cross-validation under both subject-dependent and strict subject-independent protocols on a primary resting-state dataset, with additional subject-independent validation on an odor EEG dataset. Under subject-independent evaluation on the odor dataset, the proposed model achieved an accuracy of 0.956 ± 0.051, with ROC-AUC of 0.971 ± 0.051 and PR-AUC of 0.934 ± 0.132. UMAP-based visualization and explainable AI analyses (SHAP and LIME) provide interpretable insight into the learned spatiotemporal patterns and sample-specific decisions. These results demonstrate robust, interpretable EEG-based MCI detection with potential clinical utility.
PMID:42108320 | DOI:10.1186/s40708-026-00302-4
