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Nevin Manimala Statistics

Proportional Odds or Win Probability as Methods for Assessing Ordinal Outcomes in Infectious Disease Clinical Trials

J Infect Dis. 2026 May 18:jiag193. doi: 10.1093/infdis/jiag193. Online ahead of print.

ABSTRACT

Infectious disease trials have long used ordinal outcomes, or ranked categorical scales, to capture the full spectrum of response to an intervention. We review 2 summary statistics for ordinal outcomes: the proportional odds ratio (pOR) and the win probability. The pOR asks: How much more likely is a treated participant to be in an improved category compared with control? The win probability asks: In a random treatment-control pair, what is the chance the treated participant fares better? We also introduce visual companions, the stacked-bar chart and bubble plot, to make ordinal trial results more accessible and interpretable.

PMID:42149490 | DOI:10.1093/infdis/jiag193

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