Semin Ophthalmol. 2026 Jul 5:1-7. doi: 10.1080/08820538.2026.2699401. Online ahead of print.
ABSTRACT
PURPOSE: To compare the changes in corneal endothelium and anterior segment parameters following neodymium:yttrium-aluminum-garnet (Nd:YAG) laser capsulotomy in eyes with and without pseudoexfoliation syndrome (PEX).
METHODS: Our study included 72 eyes with posterior capsular opacification (PCO). Patients were divided into two groups: PEX and control. All patients underwent detailed examination followed by Nd:YAG laser. Corneal endothelium was evaluated using specular microscopy, and anterior segment parameters were assessed using Sirius corneal topography before laser, at 1 week and 1 month post-laser. Findings were compared between PEX and control groups.
RESULTS: Of the 72 eyes, 30 were in the PEX group and 42 in the control group. There was no difference between groups in terms of baseline demographic, clinical data, and laser parameters (p > .05). Although mean pre-laser endothelial cell density (ECD) was lower in the PEX group, the difference was not statistically significant (p = .121). Significant improvement in BCVA was observed in both groups after laser (p < .001), but no significant changes were noted in intraocular pressure (IOP) or anterior segment parameters. Post-laser ECD values decreased significantly in the PEX group (p = .032), while no change was observed in the control group (p = .246). No significant correlation was found between laser energy parameters and clinical variables.
CONCLUSION: A significant decrease in ECD was observed in the PEX group after Nd:YAG laser, whereas this difference was not prominent in the control group. Our results suggest that evaluating ECD before Nd:YAG laser may help minimize potential endothelial damage, especially in patients with PEX.
PMID:42402671 | DOI:10.1080/08820538.2026.2699401
