Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2026 Jul;40(7):676-681. doi: 10.13201/j.issn.2096-7993.2026.07.014.
ABSTRACT
Objective:To explore the superimposed effects of the severity of chronic rhinosinusitis with nasal polyps（CRSwNP） and Th2-type inflammatory comorbidities（allergic rhinitis/asthma） on 25-hydroxyvitamin D[25（OH） D]and pulmonary function. Methods:A total of 159 patients with CRSwNP were retrospectively enrolled and divided into 4 groups according to comorbidities（single disease group, AR group, asthma group, AR+ asthma group）. CT Lund-Mackay score, endoscopic Lund-Kennedy score, pulmonary function（FEV1.0/FVC）, serum 25（OH） D and eosinophil proportion（EOS%） were evaluated. Analysis of variance, partial correlation and logistic regression were used for statistical analysis. Results:The comorbidity group had significantly aggravated sinonasal inflammation and lung function damage: Lund-Kennedy score（14.740±5.465 vs Single disease group: 8.49±4.02, P<0.001）, EOS%（13.68%±3.47% vs 3.95%±2.13%, P<0.001） were the highest, and 25（OH） D[（20.22±8.20）nmol/L vs （41.55±14.37）nmol/L, P<0.001] was the lowest, and pulmonary function limitation（FEV1.0/FVC=77.15%±15.92% vs 97.43%±14.01%） was the most significant（P<0.001）. Multivariate regression analysis showed that comorbidity group（odds ratio, OR=2.482, 95%CI 1.350-4.562） and Lund-Kennedy score（OR=1.583, 95%CI 1.358-1.844） were independent risk factors for 25（OH） D deficiency. Both of them also significantly predicted lung function limitation（OR=5.341, 1.414）. The ROC curve confirmed that a Lund-Kennedy score of ≥14 predicted a 92.5% sensitivity for vitamin D deficiency, and a score of ≥11 predicted a 100% sensitivity for pulmonary function limitation. Conclusion:A Lund-Kennedy score of ≥14 and 11 are high-risk warning indicators for 25（OH） D deficiency and restricted lung function. Sinonasal lesions in severe CRSwNP coexisting with Th2-type inflammation are accompanied by more significant 25（OH） D deficiency and lung function impairment. Clinically, such patients need to be monitored more closely.
PMID:42402689 | DOI:10.13201/j.issn.2096-7993.2026.07.014
