Int J Oncol. 2026 Sep;69(3):98. doi: 10.3892/ijo.2026.5911. Epub 2026 Jul 10.
ABSTRACT
Kv10.1, also known as Eag1 or KCNH1, is a voltage‑gated potassium ion channel, which exists in cell membrane and is closely associated with cancer and multiple precancerous lesions. Emerging experimental evidence shows that Kv10.1 is essential for the occurrence, growth, metastasis, proliferation and death of various malignant tumors. The pathogenesis of Kv10.1 and the signal pathways involved in its regulation are different in different cancers. The present review explored the origin, structure, distribution in normal and tumor cells, physiological and pathological characteristics, roles in cancer and tumor regulation mechanisms of Kv10.1. Finally, Kv10.1 related signaling pathways and its current use as a pharmacological modulator are summarized, aiming to provide new insights into the pharmacological research of Kv10.1 in cancer.
PMID:42429056 | DOI:10.3892/ijo.2026.5911
