Int J Dent Hyg. 2021 Aug 22. doi: 10.1111/idh.12547. Online ahead of print.
ABSTRACT
OBJECTIVE: Periodontitis is a chronic inflammatory disease initiated by dysbiotic microbiota. Conventional mechanical debridement often needs adjunctive measures to control the disease process. The objective of the present study was to find out benefit of ozonized water irrigation along with nonsurgical periodontal therapy for the management of periodontitis.
METHODS: We have conducted a Randomized Controlled, triple blinded, parallel group clinical trial. Test Group (n=25) was treated with ozonized water irrigation whereas control group (n=25) received normal saline irrigation along with mechanical debridement. Full mouth plaque score, bleeding score, probing pocket depth and clinical attachment loss were evaluated at baseline and 4 weeks after treatment. Salivary Interleukin 1 beta was analyzed using enzyme linked immunosorbent assay. Analysis of covariance, t test and chi square test were used for intergroup comparison. Intragroup comparison was done using paired t test.
RESULTS: Adjunctive ozone water irrigation resulted in significant improvement in all clinical parameters except probing pocket depth after adjusting the extraneous effects due to initial confounding factors(p<0.001). But as per subgroup analysis ozone water irrigation resulted in significant reduction of pocket depth in deep pockets (p=0.01) and number of sites with pocket depth ≥4mm with bleeding on probing. Salivary Interleukin 1 Beta also reduced significantly in test group after therapy.
CONCLUSION: Ozone irrigation provide adjunctive benefit along with nonsurgical periodontal therapy in reducing clinical parameters as well as inflammatory mediator in saliva. But long- term benefits need to be assessed with future studies.
PMID:34420261 | DOI:10.1111/idh.12547
