Zhonghua Wai Ke Za Zhi. 2026 Aug 31;64(10):1115-1120. doi: 10.3760/cma.j.cn112139-20251120-00538. Online ahead of print.
ABSTRACT
Objective: To investigate the prevalence and the risk factors of gallstone in Xuhui District of Shanghai,providing a scientific basis for developing targeted prevention and control measures. Methods: This is a cross-sectional study,which was conducted on permanent resident elderly individuals aged 65 and above who had established health records and completed annual health examinations between January and December 2024,across 13 community health centers in Xuhui District,Shanghai. A total of 48 844 elderly participants were included in the study, including 21 483 males and 27 361 females, aged (72.0±6.1) years (range: 65 to 106 years). The gender, age, height, weight, results of fasting venous blood and ultrasound results were collected.The absolute standardized mean difference (ASMD) was calculated to assess the balance of covariates between groups.Based on the presence of gallbladder stones detected by ultrasonography, the participants were divided into the study group and the control group. Rank-sum test and χ2 test were used for data analysis, and logistic regression analysis was performed to explore the risk factors for gallbladder stone formation. Results: The ASMD values of the total population and study sample were all≤0.2. The overall prevalence of gallstone in the study population was 14.44% (7 054/48 844), with a prevalence of 13.67% (3 741/27 361) in female and 15.42% (3 313/21 483) in males The prevalence of gallbladder polyps was 5.50%(2 682/48 844).The proportion of fatty liver was 45.50%(22 224/48 844). Additionally, a statistically significant difference in total cholesterol levels was observed between the gallstone group (range:4.34 to 5.77 mmol/L) and the non-gallstone groups (range: 4.39 to 5.82 mmol/L)(Z=-2.093, P<0.05). Multivariate Logistic regression analysis revealed that body mass index (BMI) ≥28 kg/m2 (OR=1.19, 95%CI: 1.17 to 1.20) and fatty liver disease (OR=1.22, 95%CI: 1.05 to 1.41) were independent influencing factors for gallstone formation (both P<0.05). Compared with the 65 to 69 years group, the risks of gallstones were significantly higher in the 70 to 74 years group (OR=1.25, 95%CI: 1.05 to 1.48) and the group aged 80 years and above (OR=1.28, 95%CI: 1.03 to 1.61). Conclusions: The prevalence of gallstone is relatively high among the elderly population in Xuhui District, Shanghai. BMI ≥28 kg/m2 and fatty liver disease are independent risk factors for gallstones. Compared with people aged 65 to 69 years, those aged 70 to 74 years and ≥80 years have an increased risk of developing gallstones.
PMID:42669448 | DOI:10.3760/cma.j.cn112139-20251120-00538
