Eur J Neurol. 2021 Nov 22. doi: 10.1111/ene.15193. Online ahead of print.
ABSTRACT
BACKGROUND: A sensitive and frequent clinical sign of a vestibular tone imbalance is the tilt of the perceived subjective visual vertical (SVV). So far there are no data yet focusing on lesion location at the cortical level as a factor for predicting compensation from tilt of SVV.
METHODS: With modern voxelwise lesion-behavior mapping (VLBM) analysis, the present study determines whether lesion location in 23 right-hemispheric cortical stroke patients with an otolith dysfunction could predict the compensation of a vestibular tone imbalance in the chronic stage.
RESULTS: Our statistical anatomical lesion analysis revealed that lesions of the posterior insular cortex (IC) are involved in vestibular otolith compensation.
CONCLUSION: The IC appears to be a critical anatomical region for predicting a tilt of SVV as a chronic disorder in stroke patients.
PMID:34808013 | DOI:10.1111/ene.15193
