Retina. 2021 Dec 15. doi: 10.1097/IAE.0000000000003378. Online ahead of print.
ABSTRACT
PURPOSE: To compare the choroidal characteristics between the eyes of patients with and without hereditary transthyretin amyloidosis (hTTRA).
METHODS: Case-control observational study with choroidal thickness and vasculature evaluation by Optical Coherence Tomography with Enhanced Depth Imaging protocol (OCT-EDI) of the macula.
RESULTS: The study included 332 eyes: 166 eyes of hTTRA patients and 166 eyes of healthy patients. Mean age was similar between groups (p=0.979). For hTTRA patients, on average, in all sectors analysed (in the full 5mm-width image (G) and also in 1mm-width central (C), nasal (N), and temporal (T) sectors), there was a higher stromal area (SA), a lower choroidal thickness (CT) and a lower choroidal vascularity index (CVI), compared to the control group. The linear mixed models revealed no differences according to the systemic treatment groups.
CONCLUSION: hTTRA patients showed statistically significant differences in choroidal characteristics, compared to eyes without pathology. These age-related and statistically significant changes compared to the healthy eyes may help in the future to better monitor the systemic hTTRA disease and complement other systemic evaluations, including on clinical trials to analyse more objective the results of new therapies.
PMID:34923509 | DOI:10.1097/IAE.0000000000003378
