Int J Infect Dis. 2022 Jan 19:S1201-9712(22)00016-9. doi: 10.1016/j.ijid.2022.01.016. Online ahead of print.
ABSTRACT
BACKGROUND: It is not clear whether previous thyroid diseases influence the course and outcomes of COVID-19.
METHODS: The study is a part of a multicentric cohort of patients with confirmed COVID-19 diagnosis from 37 hospitals. Matching for age, sex, number of comorbidities and hospital was performed for the paired analysis.
RESULTS: From 7,762 COVID-19 patients, 526 had previously diagnosed hypothyroidism and 526 were matched controls. The median age was 70 years-old and 68.3% were females. The prevalence of comorbidities was similar, except for coronary and chronic kidney diseases that were higher in the hypothyroidism group (p=0.015 and p=0.001). D-dimer levels were lower in hypothyroid patients (p=0.037). In-hospital management was similar, but hospital length-of-stay (p=0.029) and mechanical ventilation requirement (p=0.006) were lower for patients with hypothyroidism. There was a trend of lower in-hospital mortality in patients with hypothyroidism (22.1% vs. 27.0%; p=0.062).
CONCLUSION: Patients with hypothyroidism had a lower requirement of mechanical ventilation, and showed a trend of lower in-hospital mortality. Therefore, hypothyroidism does not seem to be associated with a worse prognosis.
PMID:35065257 | DOI:10.1016/j.ijid.2022.01.016
