Hepatol Res. 2022 Jan 25. doi: 10.1111/hepr.13748. Online ahead of print.
ABSTRACT
AIM: The present study focused on the association of early bevacizumab (Bev) interruption with the clinical outcome of atezolizumab plus bevacizumab (Atez/Bev).
METHODS: This retrospective study included 239 advanced hepatocellular carcinoma (HCC) patients receiving Atez/Bev from September 2020 and June 2021 at 16 different institutions in Japan. We conducted a nine-week landmark analysis to investigate the association of Bev interruption due to adverse events with the therapeutic efficacy.
RESULTS: The median age was 73.0 (68.0-80.0) years old, with 195 (81.6%) men. The objective response rate was significantly higher in patients without Bev interruption than in those with it (34.5% vs. 17.3%, p=0.038). The median progression-free survival (PFS) was 6.5 months (95% confidence interval [CI] 4.5-9.7) and 9.0 months (95% CI 7.1-not applicable) in patients with and without Bev interruption, respectively, with statistical significance (p=0.021). The 12-month overall survival (OS) rates in patients with and without Be% CI 27.7%-67.9%) and 82.2% (95% CI 70.3%-89.6%), respectively, showing a significant difference (p=0.004). The presence of Bev interruption was a significant factor associated with the PFS (p=0.021), and OS (p=0.008). A multivariate analysis showed that mALBI 2b (p<0.001) and later-line treatment (p=0.018) were unfavorable factors associated with Bev interruption. Liver injury, appetite loss, protein urea, and ascites or hepatic edema were more frequently found in patients with Bev interruption than in those without it.
CONCLUSIONS: Early Bev interruption was an unfavorable factor associated with the PFS and OS. The good liver function and treatment settings may be associated with maintaining Bev treatment. This article is protected by copyright. All rights reserved.
PMID:35080087 | DOI:10.1111/hepr.13748
