Semin Liver Dis. 2022 Feb 21. doi: 10.1055/a-1777-6112. Online ahead of print.
ABSTRACT
Micro-elimination targets specific sub-populations and/or geographic settings for hepatitis C virus (HCV) elimination. This review reports on global HCV micro-elimination literature published from 2013-2020. Data were extracted from publications to report a score based on the four key components defining micro-elimination. Sustained virologic response (SVR) and treatment initiation proportions were calculated for each manuscript and grouped means of these estimates were compared depending on micro-elimination score and care setting. 83% of the studies were from high-income settings and mainly included people who use drugs or those incarcerated. Among manuscripts, 18 had ‘low’ micro-elimination scores, 11 had ‘high’ scores and the differences in mean proportion who initiated treatment and achieved SVR between low and high score groups were statistically significant. Micro-elimination can be a useful complementary strategy for driving engagement in HCV treatment and cure. Our analysis suggests that adhering to more of the core micro-elimination components can improve outcomes.
PMID:35189667 | DOI:10.1055/a-1777-6112
