Microbes Infect. 2022 Apr 2:104976. doi: 10.1016/j.micinf.2022.104976. Online ahead of print.
ABSTRACT
One of the most urgent needs worldwide is to vaccinate against SARS-CoV-2 as many people as possible. We evaluated humoral response to Comirnaty vaccine in Thalassemia Major patients (TM). We measured SARS-CoV-2-specific antibodies against Spike protein in 57 TM patients and 58 healthy blood donors (HBD). TM and HBD subjects revealed a homogeneous serological response to the Comirnaty (Mean±SD; TM=1917,21±1384,49; HBD=2039,81±1064,44; p=0,5884). No statistically significant differences were observed among two groups. Interestingly, we observed in 73.3% of asplenic patients Ab-S titres above 800 BAU, whereas only in 26% of non splenectomized patients showed Ab-S titres above 800 BAU). This differences were statistically significant p< 0.039. Further measurement on other Ab types was needed for better understanding humoral response to Comirnaty.
PMID:35381359 | DOI:10.1016/j.micinf.2022.104976
