Neurodegener Dis Manag. 2022 Jul 18. doi: 10.2217/nmt-2022-0005. Online ahead of print.
ABSTRACT
Aim: The present study was conducted to assess the impact of gene (vitamin D receptor [VDR] polymorphisms) – environment (serum vitamin D and calcium levels) interaction on multiple sclerosis (MS) risk. Materials & methods: FokI, BsmI, TaqI and ApaI genotyping were performed in 149 MS patients and 127 controls. We measured serum vitamin D and calcium levels. Results: No significant difference between VDR polymorphisms and MS risk was detected. In patients with FokI ff, BsmI Bb, TaqI Tt and ApaI AA genotypes, vitamin D levels were statistically higher. Serum calcium levels were significantly lower in patients with FokI FF, Ff, all BsmI and TaqI genotypes and ApaI AA and Aa genotypes. Conclusion: No significant association was found between VDR polymorphisms with MS risk.
PMID:35848285 | DOI:10.2217/nmt-2022-0005
