Int J Cancer. 2022 Jul 29. doi: 10.1002/ijc.34230. Online ahead of print.
ABSTRACT
Data on diet and survival among people with metastatic colorectal cancer are limited. We examined dietary fat in relation to all-cause mortality and cancer progression or death among 1,149 people in the Cancer and Leukemia Group B (Alliance)/Southwest Oncology Group (SWOG) 80405 trial who completed a food frequency questionnaire at initiation of treatment for advanced or metastatic colorectal cancer. We examined saturated; monounsaturated; total and specific types (n-3, long-chain n-3, and n-6) of polyunsaturated fat; animal; and vegetable fats. We hypothesized higher vegetable fat intake would be associated with lower risk of all-cause mortality and cancer progression. We used Cox proportional hazards regression to estimate adjusted hazard ratios (HR) and 95% confidence intervals (CI). Over median follow-up of 6.1 years [interquartile range (IQR): 5.3, 7.2 y], we observed 974 deaths and 1,077 events of progression or death. Participants had a median age of 59 y; 41% were female and 86% identified as White. Moderate or higher vegetable fat was associated with lower risk of mortality and cancer progression or death [HRs comparing 2nd , 3rd , and 4th to 1st quartile for all-cause mortality: 0.74 (0.62, 0.90); 0.75 (0.61, 0.91); 0.79 (0.63, 1.00); p-trend: 0.12; for cancer progression or death: 0.74 (0.62, 0.89); 0.78 (0.64, 0.95); 0.71 (0.57, 0.88); p-trend: 0.01]. No other fat type was associated with all-cause mortality and cancer progression or death. Moderate or higher vegetable fat intake may be associated with lower risk of cancer progression or death among people with metastatic colorectal cancer.
PMID:35904874 | DOI:10.1002/ijc.34230
