Zh Nevrol Psikhiatr Im S S Korsakova. 2022;122(9):104-109. doi: 10.17116/jnevro2022122091104.
ABSTRACT
OBJECTIVE: To study the cerebral hemodynamics and executive functioning in patients with alcohol use disorders.
MATERIAL AND METHODS: We studied 58 patients with alcohol use disorders aged 30 to 55 years and 40 healthy controls. Rheoencephalography was used to detect cerebrovascular changes. Executive functioning was assessed using the Go-No-Go, Corsi, and Color Stroop tests.
RESULTS: Patients with alcohol use disorders have higher values of the tone of resistive vessels and medium – caliber arteries, as well as lower indicators of volumetric pulse blood filling and elastic properties of the main arteries in both right and left leads compared with the controls (p≤0.003). Patients with alcohol dependence had lower rates in all studied cognitive tests compared to the norm (p≤0.011). We also found statistically significant correlations between the studied parameters in patients with alcohol use disorders: a decrease in volumetric pulse blood filling correlated with impaired psychomotor response in the Go-No-Go task (errors on the Go signal) (rs=-0.36; p=0.048), as well as cognitive flexibility in the Stroop test (rs=-0.40; p=0.024).
CONCLUSION: Disturbances of the psychomotor reaction and cognitive flexibility in alcohol dependence are due to the regional changes (decrease) in cerebral blood flow, as well as to a decrease in the elasticity of the wall of cerebral vessels.
PMID:36168694 | DOI:10.17116/jnevro2022122091104
