Clin Transl Gastroenterol. 2022 Oct 6. doi: 10.14309/ctg.0000000000000540. Online ahead of print.
ABSTRACT
BACKGROUND: We compared esophageal mucosal gene transcript expression in proton pump inhibitor (PPI) responsive (PPI-R) eosinophilic esophagitis (EoE), PPI non-responsive (PPI-NR) EoE, and healthy controls.
METHODS: Transcript expression in mid-esophagus biopsies was determined using Nanostring and a custom panel of EoE-specific genes. The top up/downregulated genes with ≥2-fold difference in expression and statistically significant (P<0.05) were identified.
RESULTS: Nearly all of the top upregulated (17 out of 20) and downregulated (5 out of 5) genes in EoE, compared to healthy controls, were shared between the PPI-R and PPI-NR groups.
CONCLUSION: Esophageal mucosal transcript expressions are remarkably similar in PPI-R and PPI-NR EoE compared to healthy controls.
PMID:36201660 | DOI:10.14309/ctg.0000000000000540
