Retina. 2022 Oct 3. doi: 10.1097/IAE.0000000000003639. Online ahead of print.
ABSTRACT
PURPOSE: To describe characteristics of indocyanine green (ICG) angiographic plaques in the nonexudative fellow eye of Caucasian patients with unilateral treatment-naïve exudative neovascular age-related macular degeneration (nAMD) through optical coherence tomography (OCT) and OCT angiography (OCTA).
METHODS: In this retrospective cross-sectional study, nonexudative eyes with ICG angiographic plaques were analyzed by OCT B-scans for the sensitivity of a double-layer sign (DLS), a pigment epithelium detachment (PED), outer retinal atrophy (ORA), hyperreflective dots (HRD) and subretinal hyperreflective material (SRHM). The ICG angiographic plaque was matched with a macular neovascularization (MNV) in OCTA en-face scans and color-coded B-scans.
RESULTS: In total, 35 ICG angiographic plaques in 33 of 291 (11%) nonexudative eyes were diagnosed. OCT revealed: 27 DLS (78%), 8 PED (23%), 8 ORA (23%), 8 HRD (23%), 1 SRHM (3%). OCTA confirmed a MNV in 28 plaques (80%): 7 (20%) in en-face scans, 3 (9%) in color-coded B-scans and 18 (51%) in both. The area size in OCTA was significantly smaller as compared to ICG angiography (p=0,002).
CONCLUSION: The diagnosis of an ICG angiographic plaque in nonexudative fellow eyes of Caucasians with unilateral treatment-naïve exudative nAMD was highly suggestive of a typical MNV type 1 as characterized by OCT and OCTA.
PMID:36201752 | DOI:10.1097/IAE.0000000000003639
